• It is established that hypoxia can induce autophagy

  2019-05-30

  

  It is established that hypoxia can induce autophagy [32,34–37]. We evidenced the autophagic activation in the cultured human osteosarcoma MG-63 dna ligase after incubation in 1% O2 for 24h. The concomitantly elevated LC3 protein levels with HIF-1α high expression on OS tissue sections also indicates

• Many studies over the past years

  2019-05-30

  

  Many studies over the past 20 years have shown the potential of urinary markers in the detection of the presence of bone metastases [3–11], the use of urinary markers for its prognostic value in bone disease [2,4,12–20], as well as directing therapy for bone metastases patients [2,6,12–18,21–25]. Th

• A decreasing trend in CRT D implantation has been reported

  2019-05-30

  

  A decreasing trend in CRT-D implantation has been reported recently, based on the database from the National Inpatient Sample in the USA [20]. They found that advancing age and an increasing comorbidity burden were associated with a reduced likelihood of CRT-D, and speculated that the decline in CRT

• La presencia de este rbol americano detiene la

  2019-05-30

  

  La presencia de este árbol americano detiene la marcha del desterrado europeo y transforma su mirada exótica en mirada unificadora y productiva sobre el espacio americano. La subversión que realizan los traductores americanos consiste en quitarle a la naturaleza americana cualquier rastro de exotism

• Emergency care inherently addresses the wide array of

  2019-05-30

  

  Emergency care inherently addresses the wide array of illness and injury, including traumatic injuries, surgical disease, acute complications of chronic illness (eg, strokes, myocardial infarction, diabetic ketoacidosis, complications of HIV, tuberculosis, hepatitis C, and other chronic infections),

• A first step forward would

  2019-05-30

  

  A first step forward would be to establish a public-health-oriented commission or agency charged specifically with developing controls over the alcohol market and a strategy for reducing levels of alcohol consumption and problems, drawing on the strategies agreed on in the WHO Global Strategy for Re

• br This year marks years since countries signed the Beijing

  2019-05-30

  

  This year marks 20 years since 189 countries signed the Beijing Declaration and Platform for Action and committed to prioritisation of women\'s empowerment and gender equality. Yet a recently released UN analysis shows that violence against women persists at “alarmingly high levels”. Worldwide, on

• Azacitidine was administered at a dose of mg m daily

  2019-05-29

  

  Azacitidine was administered at a dose of 75mg/m2/daily subcutaneously for 7 consecutive days every 28days. Transient neutropenia was observed until the seventh ras gtpase of the azacitidine treatment was completed. A gradual increase in his blood cell count was noted and the patient eventually beca

• Amiodarone has been used in Japan

  2019-05-29

  

  Amiodarone has been used in Japan for more than 5 years now since its approval in July 2007, and intravenous amiodarone has been widely used for life-threatening ventricular tachycardia in the setting of critical care medicine. However, only few reports have been published in the international liter

• New ACLS guidelines emphasize the

  2019-05-29

  

  New ACLS guidelines emphasize the importance of external chest compressions (ECCs), stressing that ECCs should be performed to the correct depth and frequency to guarantee effectiveness [61]. Without gravity, the crewmembers cannot do ECCs in the same way as in a hospital because of Newton\'s third

• Introduction This document does not address the indications

  2019-05-29

  

  Introduction This document does not address the indications of genetic testing in patients affected by inherited arrhythmias and their family members. Diagnostic, prognostic, and therapeutic implications of the results of genetic testing also are not included in this document because this topic has

• However during pacing at the most proximal CS electrodes CS

  2019-05-29

  

  However, during pacing at the most proximal CS electrodes (CS 9–10), although the conduction time to the CS 1–2 was prolonged, the septal to lateral activation sequence (CS 5–6 to CS 3–4 to CS 1–2) indicated the presence of residual conduction on the MI line (Fig. 3B). Detailed mapping on the MI lin

• In a revised consensus statement for

  2019-05-29

  

  In 2012, a revised consensus statement for AF surgery was published by the Heart Rhythm Society/European Heart Rhythm Association/European Cardiac Arrhythmia Society as a part of the “Expert consensus statement for catheter and surgical ablation for AF” [7]. The statement was focused mainly on the r

• The efficiency of additional strategies

  2019-05-29

  

  The efficiency of 2 additional strategies for eliminating the substrate for AF maintenance in addition to PVI has been described. Linear lesions are commonly made at the roof between the contralateral superior PVs (roof line), and at the isthmus between the mitral valve and the left inferior PV (mit

• br Introduction The early repolarization ER pattern has

  2019-05-29

  

  Introduction The early repolarization (ER) pattern has been considered a benign electrocardiographic phenomenon affecting 2–5% of the general population and is most commonly seen in healthy young men and athletes [1–3]. Recent studies have challenged the view of this electrocardiogram (ECG) varia

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