• br CaMKII and heart failure progression CaMKII is a

  2019-05-24

  

  CaMKII and heart failure progression CaMKII is a multifunctional serine–threonine kinase, phosphorylating target proteins. Under resting conditions, CaMKII is inactive. A rise in intracellular Ca2+ stimulates binding of Ca2+ to calmodulin (CaM), a ubiquitous Ca2+-binding protein. The Ca2+/CaM com

• All patients engrafted patient Patient developed secondary

  2019-05-23

  

  All patients engrafted; 1 patient (Patient 6) developed secondary graft rejection following an A antigen mismatched graft from a male sibling and went on to receive a VUD HSCT with a female donor. There were no major conditioning related toxicities. Bacterial infections occurred in 6 patients prior

• Introduction Acute myeloid leukemia AML is a rare disease af

  2019-05-23

  

  Introduction Acute myeloid leukemia (AML) is a rare disease afflicting annually 3–4 persons per 100,000 individuals. With a median age at diagnosis of 67 years, this disease is far more common in the elderly [1]. In this age group, AML has a particularly dismal outcome with less than 5% of the pati

• By showing the great variability in surgical outcomes

  2019-05-23

  

  By showing the great variability in surgical outcomes across LMICs, Uribe-Leitz and colleagues have shared with the world instructive knowledge that aids our ongoing advocacy efforts to promote quality in surgical care in resource-limited settings. Ultimately, for destitute sick and injured patients

• Fig shows the percentage of patients with high D

  2019-05-23

  

  Fig. 2 shows the percentage of patients with high D-dimer levels in relation to the CHA2DS2–VASc scores and BNP levels. None of the patients had a CHA2DS2–VASc score of 0. The BNP levels were elevated in 3 (38%) of the 8 patients with CHA2DS2–VASc scores of 1, and the D-dimer levels were elevated in

• Others have observed the marked differences in clinicopathol

  2019-05-23

  

  Others have observed the marked differences in clinicopathological characteristics between breast cancer subtypes by IHC study. However, they reported that triple negative and HER2 patients are at high risk of recurrences after adjusting for age, stage and histological grade. Our data support this o

• Findings Final data analysis included households nine from t

  2019-05-23

  

  Findings Final data analysis included 28 households: nine from the Tulip filter group, 10 from Waterguard chlorination, and nine from the group who boiled water. Two households had incomplete data and were excluded from analysis. Before the intervention, 29 of 30 households were not treating their w

• As en m s de

  2019-05-23

  

  Así, en más de un sentido, las crónicas de Indias pueden ser pensadas como textos en los que el yo comienza ldv mostrar, de manera incipiente, la crisis de este momento de clivaje en la historia, momento de pasaje del mundo medieval al mundo moderno, estrechamente atravesado por la experiencia de la

• Se antes Jos Mart em Cuba em com

  2019-05-23

  

  Se antes José Martí em Cuba, em 1891, com Nuestra América, e logo, em 1900, José Enrique Rodó com Ariel, propugnavam uma alteridade diversa dos Estados Unidos para os latino-americanos pós-independência, por exemplo, Dipesh Chakrabarty, em Provincializing Europe, reelaborou essas e aquelas consignas

• Splicing machinery dysfunctions have been associated

  2019-05-23

  

  Splicing machinery dysfunctions have been associated to CLL, in particular gene mutations (splicing factor 3B subunit 1) which are present in about 15% of patients . To our knowledge, no gene mutation has ever been detected in CLL. In order to broaden our knowledge on the frequency of splicing mu

• years ago published a groundbreaking and

  2019-05-23

  

  5 years ago, published a groundbreaking (and taboo-breaking) Series on stillbirths. Its powerful mix of advocacy and hard data attracted more media attention than perhaps any other Series, and made waves on numerous levels, from the individual to the intergovernmental. Working closely with countrie

• One of the unheralded developments in global health is

  2019-05-23

  

  One of the unheralded developments in global health is the welcome increase in the number of older people (ie, aged 60 or 65 years and older) in low-income and middle-income countries. In parallel with the gains from this longevity dividend, ageing presents particular challenges to health services.

• br Conclusion br Conflict of interest statement br Authors c

  2019-05-23

  

  Conclusion Conflict of interest statement Authors\' contribution Introduction There are two classes of bisphosphonates that differ with regard to structure and mechanism of action [1]. The first one includes pyrophosphate-resembling bisphosphonates, such as clodronate and etidronate, whi

• br Conflict of interest br Introduction The

  2019-05-22

  

  Conflict of interest Introduction The use of implantable defibrillation devices such as an implantable cardioverter–defibrillator (ICD) or a cardiac resynchronization therapy device with a defibrillator (CRT-D) is the primary therapy for improving prognoses of patients with life-threatening ve

• br Discussion We evaluated and determined

  2019-05-22

  

  Discussion We evaluated and determined the incidence and severity of subjective reports of dyspepsia symptoms due to dabigatran. Based on the results of the RE-LY trial [4], the AE that was significantly more common with dabigatran than with warfarin was dyspepsia. In the sub-group (326 Japanese

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