• The zebrafish Danio rerio is a popular model organism for

  2023-10-07

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• br Methods and results ACE is a Canadian

  2023-10-07

  

  Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric EI1 spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes but also provide

• Later the same group designed and prepared several steroidal

  2023-10-07

  

  Later, the same group designed and prepared several Δ16-steroidal C17 benzoazoles and pyrazines and evaluated their CYP17 and 5α-reductase inhibitory activities, binding to and transactivation of the AR, as well as their antiproliferative effects against two human PC cell lines (LNCaP and LAPC4) [18

• br Acknowledgements Authors wish to thank Sabanci University

  2023-10-07

  

  Acknowledgements Authors wish to thank Sabanci University (Turkey), Tubitak (Cost Eu-Ros, 113Z463), and the University of Turin (Italy) for supporting this work. Beyza Vurusaner is supported by Sabanci University Post-doctoral research scholarship. Introduction Endometriosis is defined as the

• An alternative more rarely used electron

  2023-10-07

  

  An alternative, more rarely used, electron microscopy-based approach exploits labeling of phagosomes with DAMP (3-(2,4-dinitroanilino)-30-amino-N-methyldipropylamine). DAMP is a weakly basic compound which is membrane-impermeable once it has been protonated. This way, DAMPH+ accumulates in acidic in

• Several studies have demonstrated that depletion

  2023-10-07

  

  Several studies have demonstrated that depletion of functional ATR increases the sensitivity of cancer cells to oncogene-induced replication stress thereby hindering tumour growth and inducing extensive cell death (Gilad et al., 2010, Murga et al., 2011, Schoppy et al., 2012). Importantly, Schoppy e

• A high throughput screening campaign led to the discovery

  2023-10-07

  

  A high-throughput screening campaign led to the discovery of the first series of both potent and selective ATR kinase inhibitors by Vertex Pharmaceuticals (Charrier et al., 2011). One of these compounds, VE-821, was shown to be a potent ATP-competitive inhibitor of ATR with minimal cross-reactivity

• br Results br Discussion ER and GR play

  2023-10-07

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• Furthermore we also found that the

  2023-10-07

  

  Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 meclofenamate than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS observed in m

• Estradiol receptor To further evaluate the influence of anti

  2023-10-07

  

  To further evaluate the influence of Estradiol receptor on allergy, Russel et al. initiated vancomycin treatment during pregnancy in mice and continued it for several weeks after birth. This resulted in exaggerated OVA-induced allergic inflammation, characterized by higher numbers of lung eosinophi

• The Nagoya Heart Study enrolled patients with hypertension a

  2023-10-07

  

  The Nagoya Heart Study enrolled patients with hypertension and type 2 diabetes or impaired Lenalidomide tolerance (12). Patients were randomized to valsartan- or amlodipine-based regimens with a BP target of ≤130/80 mmHg. The primary outcome was a composite of sudden cardiac death, myocardial infar

• In this study using pure enzyme preparations of human placen

  2023-10-03

  

  In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis VU 591 hydrochloride with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We pres

• pde inhibitor br Hypoadiponectinemia in metabolic syndrome A

  2023-10-03

  

  Hypoadiponectinemia in metabolic syndrome APN belongs structurally to the complement 1q family and is found at high concentrations (>0.01% of total protein) in the serum of healthy individuals [6]. Given the abundance of APN in plasma, it is assumed that alterations in plasma levels of APN might

• br Experimental procedure br Introduction

  2023-10-03

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Since innate immune responses represent the first

  2023-10-03

  

  Since innate immune responses represent the first defense against incoming infectious microorganisms, they are particularly engaged during the early stages of viral infections. Many innate defense mechanisms rely on the engagement of pattern recognition receptors (PRRs) which are conserved, germ li

15967 records 269/1065 page Previous Next First page 上5页 266267268269270 下5页 Last page