• In contrast to SQLE HMGCR could be efficiently degraded in

  2020-07-22

  

  In contrast to SQLE, HMGCR could be efficiently degraded in 2,4-Diacetylphloroglucinol lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent w

• br Funding This work was

  2020-07-21

  

  Funding This work was supported by the grants from MSD, Terumo Life Science Foundation, Takeda Science Foundation, and Japan Diabetes Foundation. Disclosures Acknowledgments The authors thank C. Morimoto (Juntendo University, Tokyo, Japan) and K. Takeda (Immunology Frontier Research Center

• The notion that a small subset of inducible cellular

  2020-07-21

  

  The notion that a small subset of inducible cellular transcripts, encoding immunological important factors, is translocated across the nuclear envelope by the karyopherin CRM1 is gaining support from various recent studies. For example, experimental evidence has been provided demonstrating that the

• In this study we further investigated the involvement of CRF

  2020-07-21

  

  In this study, we further investigated the involvement of CRF1 and CRF2 receptors of the dPAG in the regulation of panic-related responses. For this, we used two animal models that associate escape behavior with panic attacks: the elevated T maze and the electrical stimulation of the dPAG (for a ful

• Allele specific methylation has been observed in CpG

  2020-07-21

  

  Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL alln and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same patients. Methyl

• The current study had the following aims br

  2020-07-21

  

  The current study had the following 3 aims: Materials and methods Results Discussion Western Europe, USA/Canada, and Australia have traditionally been the areas in which cochlear hydralazine hydrochloride is most common [9], [10]; correspondingly, the most common and well-known validated

• br Results and discussion br Conclusion This study describes

  2020-07-21

  

  Results and discussion Conclusion This study describes the development of a highly sensitive on-sorbent derivatisation technique, using the novel high-surface area CMV devices, to sample methamphetamine vapour. Previous methods for air sampling for methamphetamine such as sampling cassettes ha

• br Discussion The etiology of autoimmune diseases including

  2020-07-21

  

  Discussion The etiology of autoimmune diseases including psoriasis is intricate and a composite of environmental and biological factors. There are very limited studies available that report the association analysis of ACE I/D polymorphism with psoriasis risk. In the current study we report on ass

• br Experimental Procedure br Acknowledgment This work was su

  2020-07-21

  

  Experimental Procedure Acknowledgment This work was supported by Ministry of Education, Singapore (MoE Tier-2) grant (R-154-000-625-112) and R154-000-A72-114 (AcRF Tier 1 grant) respectively. We acknowledge the Advanced Photon Source Beamline 24-ID-C, Argonne National Laboratory, USA. D.N. is

• br The central role of DNA PK in

  2020-07-21

  

  The central role of DNA-PK in the NHEJ NHEJ can be divided in several steps (Fig. 1A): 1) recognition and binding of Ku at each ends of the DSB following by the assembly of the DNA-PK at the break points and bridging; 2) phosphorylation of the DNA ends by DNA-PKcs; 3) ligation of the ends by DNA

• Our ex vivo analysis demonstrates that IL promotes CD

  2020-07-21

  

  Our ex vivo analysis demonstrates that IL-15 promotes CD122 expression in DGKζ-deficient CD8+ T cells. CD122, which forms a dimer with CD132 in response to IL-2 or IL-15, activates the JAK/STAT and PI3K/mTOR pathways. Whereas antigen-stimulated Temsirolimus receptor promote IL-2 sensitivity through

• GLP signaling mediates important renal functions as

  2020-07-20

  

  GLP-1 signaling mediates important renal functions [101], as suggested by the expression of both DPP-4 and GLP-1R in the kidney of several species, including humans [102]. However, controversial data exists on the specific expression pattern of these proteins, based on the specificity and sensitivit

• The DDR gene located on chromosome region

  2020-07-20

  

  The DDR1 gene, located on chromosome region 6p21.33, encodes a transmembrane tyrosine kinase receptor involved in melanocyte anchoring through binding to collagen IV (Silva de Castro et al., 2010). So far, only three studies have been conducted on the association between DDR1 polymorphism and the ri

• The methods used for cytokine analysis

  2020-07-20

  

  The methods used for cytokine analysis, such as ELISA or multiplex systems could also influence the concentrations of cytokines analysed. It is therefore crucial to use the same lot of the multiplex analysis kit to make such a comparison [21]. In our study, we ensured that the analysis was performed

• Therefore in this study we determined whether exogenous LTD

  2020-07-20

  

  Therefore, in this study we determined whether exogenous LTD, a potent agonist of both CysLT and CysLT receptors , , induces ubiquitin e3 ligase edema and AQP4 expression in mouse brain; if so, which subtype of the receptors is involved in AQP4 expression in mouse brain and the cultured rat astrocyt

16085 records 831/1073 page Previous Next First page 上5页 831832833834835 下5页 Last page